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益肺健脾补肾颗粒配合西药治疗慢性阻塞性肺疾病加重期疗效观察

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摘要:目的:观察中药益肺健脾补肾颗粒配合西药万托林(硫酸沙丁醇气雾剂)治疗慢性阻塞性肺疾病加重期的临床疗效。方法:将80例慢性阻塞性肺疾病加重期患者随机分为治疗组和对照组各40例,对照组给予常规西药治疗及吸入短效β2受体激动剂硫酸沙丁醇气雾剂治疗,治疗组在对照组治疗基础上加用益肺健脾补肾颗粒治疗,两组疗程均为14天,14天后观察临床疗效、治疗前后肺功能第一秒用力呼气量(FEV1)改善情况。结果:治疗组总有效率为97.5%,对照组总有效率为85%,两组疗效比较差异有显著性(P<0.05),治疗后两组FEV1与治疗前比较均有上升,差异有显著性(P<0.05)。结论:中药益肺健脾补肾颗粒配合西药万托林治疗慢性阻塞性肺疾病有较好的临床疗效。
关键词:慢性阻塞性肺疾病; 益肺健脾补肾颗粒; 硫酸沙丁醇气雾剂; 临床观察
Abstract:Objective:To observe the therapeutic effects on the treatment of the COPD exacerbation with Yifeijianpibushen granula assisted with Ventolin(Aerosol Salbutamol Sulfate).Methods:80 patients confirmed in COPD exacerbation were randomly divided into two groups. 40 patients in the control group were treated with routine western medicine and inhalation of short acting β2-adrenergic receptor agonists(Aerosol Salbutamol Sulfate).40 patients of the treated group were treated with Yifeijianpibushen granula assisted with the western medicine mentioned in the control group. Both treatment periods were 14 days. The therapeutic effects were observed after the 14 days and FEV1 was measured before and after the treatment.Results:The clinical study showed that the therapeutic effects of the treated group were more significant than that of the control group(P<0.05). The overall cure rate of the treated group was 97.5%.The overall cure rate of the control group was 85%.We also found that FEV1 in the two groups were both increased after the treatment. Compared with the increase in both pre-treatment, the difference was significant(P<0.05). Conclusion:Yifeijianpibushen granula assisted with Ventolin(Aerosol Salbutamol Sulfate) has more significant effect in treating COPD.
Key words:COPD; Yifeijianpibushen

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granula;Aerosol Salbutamol Sulfat;clinical observation
1672-3783(2012)06-0084-01
慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)是指慢性支气管炎、肺气肿引起的不完全可逆,呈进行性加重的一组慢性阻塞性肺疾病。是临床上常见病、难治病。目前对COPD治疗越显得重要,防治手段也倾向于综合治疗。中医或中西医结合治疗本病有一定的优势,积累了许多临床经验。笔者采用益肺健脾补肾颗粒配合西药万托林治疗慢性阻塞性肺疾病加重期患者,取得较好的临床疗效,现报道如下。

1 临床资料

1.1 一般资料:观察病例选自2006-2008年本院门诊患者。诊断标准按2002年中华医学会呼吸病学会制定的《慢性阻塞性肺疾病诊断指南》。符合条件的80例COPD患者随机分为治疗组和对照组各40例。其中治疗组男29例,女11例,年龄50~75岁,平均(52±2.1)岁,有吸烟及间断吸烟者32例,无吸烟者8例,病程最短5年,最长32年;对照组男30例,女10例,年龄51~75岁,平均(51±22)岁,有吸烟及间断吸烟者33例,无吸烟者7例,病程最短4年,最长31年。两组病例性别、年龄、病程经统计学处理差异无显著性(P>0.05),具有可比性。

1.2 治疗方法

1.2.1 对照组:给予万托林(硫酸沙丁醇气雾剂)吸入 (葛兰素史克中国投资有限公司生产,批号:KR005g),根据病情程度用药,轻度者每次吸入1~2喷(100~200μg),每日3次。中度者加用氨茶碱片0.1g每日3次口服(大同长兴制药有限公司出产,批号:H14020599),同时吸氧,3L/min,治疗14天为1个疗程。

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