本站原创
【摘要】 目的：研究老年高血压患者踝肱指数与尾加压素Ⅱ（UⅡ）的相关性，进一步探讨UⅡ与动脉粥样硬化的关系。方法：采用放免法测定130例老年高血压患者及72例健康老年人血浆UⅡ浓度，并分别测量踝肱指数（ankle brachial index，ABI），再根据ABI严重程度将高血压患者分为ABI0、ABI1、ABI2三组。结合UⅡ水平、踝肱指数对各组进行比较分析。结果：与健康组比较，高血压患者踝肱指数明显降低，而血浆UⅡ水平明显升高 （P<0.01）；高血压患者血浆UⅡ水平与ABI呈明显负相关，高血压三组UⅡ水平组间比较差异有统计学意义（P<0.05）。结论：老年高血压患者的踝肱指数与血浆UⅡ水平呈负相关，提示UⅡ浓度与动脉粥样硬化密切相关。
【关键词】 高血压； 动脉粥样硬化； 尾加压素Ⅱ； 踝肱指数
The Relationship of Ankle-brachial Index and Urotensin Ⅱ in Elderly Patients with Hypertension/CHEN Wei-quan.//Medical Innovation of China，2013，10（14）：137-138
【Abstract】 Objective：To study the relationship of ankle-brachial index and urotensin Ⅱ （U Ⅱ）in elderly patients with hypertension， to explore the relationship of U Ⅱ and atherosclerosis. Method：To enroll 130 cases of elderly patients with hypertension and 72 healthy elderly，the plaa U Ⅱ concentration and the ankle-brachial index （ankle brachial index， ABI） was measured by radioimmunoassay in all cases.According to the severity of the ABI，the hypertensive patients were divided into ABI0 /ABI1/ ABI2 three groups. At last， a comprehensive analysis of U Ⅱ level， ankle-brachial index， in each group was deployed.Result：Compared with the healthy individuals， the ankle-brachial index in hypertensive patients was significantly reduced， in contrast the plaa U Ⅱ levels were significantly increased （P<0.01）.The plaa U Ⅱ level was negatively related to the ABI in hypertensive patients.The difference of U Ⅱ level in three hypertensive groups was statistically significant （P<0.05）.Conclusion：ABI in elderly hypertensive patients is negatively related with the plaa U Ⅱ level and the concentration of U Ⅱ is closely related to the Atherosclerosis.
【Key words】 Hypertension； Artery atherosclerosis； Urotensin Ⅱ； Ankle-brachial index
First-author’s address：Luoding People’s Hospital， Luoding 527200，China
doi：10.3969/j.issn.1674-4985.201
【关键词】 高血压； 动脉粥样硬化； 尾加压素Ⅱ； 踝肱指数
The Relationship of Ankle-brachial Index and Urotensin Ⅱ in Elderly Patients with Hypertension/CHEN Wei-quan.//Medical Innovation of China，2013，10（14）：137-138
【Abstract】 Objective：To study the relationship of ankle-brachial index and urotensin Ⅱ （U Ⅱ）in elderly patients with hypertension， to explore the relationship of U Ⅱ and atherosclerosis. Method：To enroll 130 cases of elderly patients with hypertension and 72 healthy elderly，the plaa U Ⅱ concentration and the ankle-brachial index （ankle brachial index， ABI） was measured by radioimmunoassay in all cases.According to the severity of the ABI，the hypertensive patients were divided into ABI0 /ABI1/ ABI2 three groups. At last， a comprehensive analysis of U Ⅱ level， ankle-brachial index， in each group was deployed.Result：Compared with the healthy individuals， the ankle-brachial index in hypertensive patients was significantly reduced， in contrast the plaa U Ⅱ levels were significantly increased （P<0.01）.The plaa U Ⅱ level was negatively related to the ABI in hypertensive patients.The difference of U Ⅱ level in three hypertensive groups was statistically significant （P<0.05）.Conclusion：ABI in elderly hypertensive patients is negatively related with the plaa U Ⅱ level and the concentration of U Ⅱ is closely related to the Atherosclerosis.
【Key words】 Hypertension； Artery atherosclerosis； Urotensin Ⅱ； Ankle-brachial index
First-author’s address：Luoding People’s Hospital， Luoding 527200，China
doi：10.3969/j.issn.1674-4985.201
3.14.079
动脉粥样硬化（AS）是多种因素引起的一种连续性、全身性疾病，是心脑血管疾病的致病基础，其中高血压病是其独立危险因素。研究发现，ABI可作为反映动脉硬化的敏感特异性指标之一 。尾加压素II（UII）是迄今发现的最强的缩血管活性物质，研究表明，UII参与了高血压的发病过程，且与多种心血管疾病的发生发展密切相关。本研究对老年高血压患者计算踝肱指数（ankle brachial index，ABI）及检测血浆UII水平，探讨UII水平与老年高血压患者动脉硬化的相关性。1 资料与方法
1.1 一般资料 130例老年高血压患者均来自本院2009年2月-2012年3月心内科住院的患者，均符合2005 年《中国高血压防治指南》制定的高血压诊断标准。其中男78例，女52例，年龄60～83岁，平均（66.52±10.83）岁。所有患者排除恶性肿瘤、糖尿病、痛风、肝、肾功能不全、感染性疾病及继发性高血压、精神疾病。选择在本院体检的72例健康老年人为健康对照组，其中男43例，女29例，源于：毕业设计论文模板www.udooo.com
年龄60～82岁，平均（65.86±10.57）岁，除外各种严重心脑血管、内分泌等系统疾病。两组患者年龄、性别等一般资料比较差异均无统计学意义（P>0.05）。1.2 方法
1.2.1 标本的采集与检测 所有研究对象于空腹采静脉血6 ml，全血离心后分离血浆置于-80 ℃低温保存待测。血浆UII采用放免法测定（标准品由美国Phoenix Pharmaceutical Inc 提供，上海博华商贸有限公司提供放免试剂盒），标本检测严格按照试剂盒的要求进行操作。源于：期刊论文www.udooo.com